🏥 GenomicsAI Clinical Laboratory 📞 +98-21-12345678 📧 support@genomicsai.pro
🗄️ Databases: ClinVar | OMIM | gnomAD | dbSNP | UniProt | ACMG ⏰ ۱۴۰۴/۰۸/۲۰
AI-Powered Clinical Genomic Analysis Platform v3.2
📋
387
Total Cases
↑ 12% vs last month
289
Completed
↑ 8%
58
Processing
Stable
🧬
12,847
Total Variants
↑ 15%
⚠️
127
Pathogenic Variants
↓ 5%
🤖
96.8%
AI Accuracy
↑ 2.1%
📊 Case Distribution by Type
📈 Variants by Classification
🔍 Database Usage
Recent Cases
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CASE-2024-1847 - Sarah Mohammad
COMPLETE
📊 WES | 📅 2024-11-18 | 🧬 2,847 variants | ⚠️ 3 Pathogenic | 🤖 AI: 98%
Epilepsy Dev. Delay SCN1A
CASE-2024-1848 - Amir Rezaei
PROCESSING
📊 WGS | 📅 2024-11-19 | ⏱️ Variant Calling 87%
Cardiac Family History
CASE-2024-1849 - Zahra Ahmadi
PENDING
📊 Cancer Panel | 📅 2024-11-17 | Waiting for upload
Breast Cancer BRCA
CASE-2024-1850 - Ali Karimi
URGENT
📊 Pharmacogenomics | 📅 2024-11-20 | 28 drugs analyzed - Warfarin dosing
PGx CYP2C9
CASE-2024-1851 - Fatima Nouri
COMPLETE
📊 WES - Trio | 📅 2024-11-15 | 🧬 4,126 variants | ⚠️ 2 De novo
Autism Trio Analysis
System Activity
Dr. Ahmadi approved CASE-1847
2 hours ago
AI Engine identified 3 Pathogenic variants
4 hours ago
System Updated ClinVar v2024.11
1 day ago
AI Model Upgraded to v3.2
2 days ago
🗄️ Database Status
ClinVar
1.2M variants
v2024.11
✓ Online
OMIM
28K+ genes
v2024.11
✓ Online
gnomAD
800M+ vars
v4.1
✓ Online
dbSNP
700M+ SNPs
v158
✓ Online
System Performance
Database Response 1.2s
API Response 0.8s
System Uptime 99.9%
Coverage Mean
85.3x
✓ PASS
Coverage >20x
98.7%
✓ PASS
Q30 Bases
94.2%
✓ PASS
Mapping Rate
99.1%
✓ PASS
Total Reads
127M
✓ PASS
Duplication Rate
8.3%
✓ PASS
Insert Size
387 bp
✓ PASS
Ti/Tv Ratio
2.08
✓ PASS
Contamination
0.3%
✓ PASS
GC Content
42.1%
✓ PASS
Coverage Distribution
Q-Score Distribution
Read Quality
All 2847
Pathogenic 3
Likely Path 8
VUS 24
Benign 2812
Gene Chr:Position Change Type Impact Classification MAF CADD REVEL ClinVar 🤖 AI Action
SCN1A chr2:166152516 c.4942C>T SNV Missense Pathogenic 0.00001 34.2 0.98 VCV000123456 🤖 98%
BRCA1 chr17:43094464 c.68_69delAG Deletion Frameshift Pathogenic - 31.0 - VCV000234567 🤖 95%
MECP2 chrX:154021565 c.473C>T SNV Missense Likely Path 0.000015 28.5 0.89 VCV000345678 🤖 92%
CFTR chr7:117559590 c.1521_1523del In-frame Del In-frame deletion VUS 0.0008 22.1 0.52 VCV000456789 🤖 67%
TP53 chr17:7674220 c.743G>T SNV Nonsense Likely Path 0.00003 36.0 - VCV000567890 🤖 89%
APOE chr19:45411941 c.388T>C SNV Missense Benign 0.145 8.3 0.12 VCV000678901 🤖 12%
📈 Copy Number Variants
🔻 Deletion
Position: chr15:22,748,589-22,791,612
Size: 43 kb
Genes: NIPA1, NIPA2
Classification: Pathogenic
🔺 Duplication
Position: chr22:18,894,835-21,440,514
Size: 2.5 Mb
Genes: Multiple
Classification: VUS
🔻 Deletion
Position: chr7:117,120,016-117,308,718
Size: 189 kb
Genes: CFTR
Classification: Likely Path
📊
CNV Visualization
Visual representation of copy number variants across genome
🔄 Runs of Homozygosity
Total ROH Regions
47
Total Length
128 Mb
Genome in ROH
4.2%
🔴 chr1:145,234,567-153,987,654
Size: 8.7 Mb | SNPs: 3,421 | Genes: 47 | Confidence: 99.8%
🔴 chr6:28,477,797-33,448,354 (HLA)
Size: 4.9 Mb | SNPs: 1,892 | Genes: 28 | Confidence: 98.5%
👨‍👩‍👧‍👦
Family Pedigree Viewer
Analyze family history and inheritance patterns
📋 Summary
3 Pathogenic and 8 Likely Pathogenic variants identified. Primary pathogenic variant in SCN1A (AI score 98%) is causative for Dravet syndrome.
🧬 Key Variants
SCN1A - Pathogenic - ClinVar: VCV000123456
c.4942C>T (p.Arg1648His) - OMIM #601769 - Dravet Syndrome - MAF 0.00001 - CADD 34.2
BRCA1 - Pathogenic - ClinVar: VCV000234567
c.68_69delAG - OMIM #113705 - Frameshift mutation - High impact
98%
AI analysis with ClinVar, OMIM, gnomAD integration confirms SCN1A as causative with 98% confidence
📋 Complete Case Management System
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🤖 AI-Powered Variant Prioritization v3.2
📊 Report Generation System
ClinVar
1.2M+ clinical variants | v2024.11
✓ Online
OMIM
28,000+ genes | v2024.11
✓ Online
gnomAD
800M+ variants | v4.1
✓ Online
dbSNP
700M+ SNPs | v158
✓ Online
UniProt
230M+ sequences | v2024.10
✓ Online
ACMG SF
73 medically actionable | v3.1
✓ Online
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